Article

Role of thyroid hormone receptor alpha in susceptibility and progression of osteoarthritis

2018-01-01

Abstract excerpt

Osteoarthritis (OA) is a debilitating joint disease characterised by articular cartilage damage, chondrocyte hypertrophy and subchondral bone changes. Thyroid hormone (TH) regulates chondrocyte differentiation, endochondral ossification and bone maintenance, acting mainly through thyroid hormone receptor alpha (TRα). Genetic, pathological and experimental data have implicated a role for TH availability in OA patho...

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Literature Corpus work: 25301275-9f4d-53bd-b88b-fa8a02ad8b4e
DOI: 10.25560/65571

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