Article
Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis.
Experimental biology and medicine (Maywood, N.J.) - 1 Jul 2015
Monfoulet Laurent-Emmanuel, Philippe Claire, Mercier Sylvie, Coxam Véronique, Wittrant Yohann
Abstract excerpt
Osteoarthritis (OA) is an age-related degenerative joint disease. To date, its management is focused on symptoms (pain and inflammation). Studies suggest that fatty acids can reduce the expression of inflammatory and catalytic mediators, and improve in vivo joint function. Free fatty acid receptors (FFARs) such as G-protein coupled receptor 40 (GPR40) are proposed as attractive therapeutic targets to counteract...
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