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Article

Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2021

Liang Yue, Zhao Defa, Wang Ranran, Dang Pingping, Xi Yue, Zhang Dan, Wang Wei, Shan Zhongyan, Teng Xiaochun, Teng Weiping

Abstract excerpt

Background: In humans, resistance to thyroid hormone (RTH) caused by mutations in the thyroid hormone receptor alpha (THRA) gene, RTHα, manifests as tissue-specific hypothyroidism and circulating thyroid hormone levels exhibit hypothyroid-like clinical features. Before the identification of patients with RTHα, several Thrα1 knock-in mouse models were generated to clarify the function of TRα1. However, the...

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PMID: 32924834
DOI: 10.1089/thy.2019.0733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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