Article

Dehydroepiandrosterone Inhibits ADAMTS Expression via an ERK-dependent Mechanism in Chondrocytes

2023-09-14

Abstract excerpt

<h4>Background: </h4> Osteoarthritis (OA) is a joint disease in which cartilage degradation is the hallmark pathological change. In this study, we investigated the anti-osteoarthritic effects of DHEA in rabbit chondrocytes. Methods and Results Polymerase chain reaction was performed to evaluate the expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, ADAMTS-5, aggrecan and coll...

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Literature Corpus work: 36d6e8da-9be2-508f-8b00-8c0a63d86b77
DOI: 10.21203/rs.3.rs-3344591/v1

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