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Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis

2022-01-18

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<title>Abstract</title> <p>Chronic inflammation plays an important role in the osteoarthritis (OA) pathology but how this influence OA disease progression is unclear. Leukotrienes (LT) are biologically active lipids that are implicated in various pathological process. Leukotriene B4 (LTB<sub>4</sub>) is a potent proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5-...

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Literature Corpus work
f955ff26-357a-52c7-a085-007a0ea94401
DOI
10.21203/rs.3.rs-1245437/v1
Open publication

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Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental OsteoarthritisDOI 10.21203/rs.3.rs-1245437/v1
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