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Article

Context-specific protection of TGFα null mice from osteoarthritis

26 Jul 2016

Abstract excerpt

Transforming growth factor alpha (TGFα) is a growth factor involved in osteoarthritis (OA). TGFα induces an OA-like phenotype in articular chondrocytes, by inhibiting matrix synthesis and promoting catabolic factor expression. To better understand TGFα's potential as a therapeutic target, we employed two in vivo OA models: (1) post-traumatic and (2) aging related OA. Ten-week old and six-month old male Tgfa null...

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PMID: 27457421
DOI: 10.1038/srep30434

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