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Article

Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA.

1 May 2014

Abstract excerpt

The goal of this study is to determine whether transforming growth factor beta 1 (Tgf-β1) induces the high temperature requirement A1 (HtrA1) in articular chondrocytes of two mouse models of osteoarthritis (OA). Early onset articular cartilage degeneration in the mouse models was characterized by histology. Expression profiles of Tgf-β1, p-Smad1, p-Smad2/3 and HtrA1 in knee joints of the mouse models were...

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Identifiers

PMID: 24135912
DOI: 10.14670/hh-29.10.609

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