Article
THRA and DIO2 mutations are unlikely to be a common cause of increased bone mineral density in euthyroid post-menopausal women.
European journal of endocrinology - 1 Apr 2014
Gogakos Apostolos, Logan John G, Waung Julian A, Bassett J H Duncan, Glüer Claus C, Reid David M, Felsenberg Dieter, Roux Christian, Eastell Richard, Williams Graham R
Abstract excerpt
OBJECTIVE: A new autosomal dominant disorder due to mutation of THRA, which encodes thyroid hormone receptor α, is characterised by severely delayed skeletal development but only slightly abnormal thyroid status. Adult mice with disrupted thyroid hormone action in bone due to a mutation of Thra or deletion of Dio2, encoding the type 2 deiodinase, have high bone mass and mineralisation despite essentially...
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