Article
Quantifying cell divisions along evolutionary lineages in cancer.
Nature genetics - 1 Mar 2025
Blohmer Martin, Cheek David M, Hung Wei-Ting, Kessler Maria, Chatzidimitriou Foivos, Wang Jiahe, Hung William, Lee I-Hsiu, Gorelick Alexander N, Wassenaar Emma Ce, Yang Ching-Yeuh, Yeh Yi-Chen, Ho Hsiang-Ling, Speiser Dorothee, Karsten Maria M, Lanuti Michael, Pai Sara I, Kranenburg Onno, Lennerz Jochen K, Chou Teh-Ying, Kloor Matthias, Naxerova Kamila
Abstract excerpt
Cell division drives somatic evolution but is challenging to quantify. We developed a framework to count cell divisions with DNA replication-related mutations in polyguanine homopolymers. Analyzing 505 samples from 37 patients, we studied the milestones of colorectal cancer evolution. Primary tumors diversify at ~250 divisions from the founder cell, while distant metastasis divergence occurs significantly later,...
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