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Article

Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinoma

2025-06-24

Abstract excerpt

High-grade pancreatic neuroendocrine carcinoma (panNEC) is a rare, aggressive cancer with limited tissue availability. Single-nucleus transcriptomics of five large-cell panNECs revealed two clinically relevant neuroendocrine cell states: one highly proliferative with an aberrant brain-specific neuronal differentiation program and another stress-responsive state enriched for heat stress, hypoxia, and glycolysis. Ou...

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Literature Corpus work
24d6be4e-60eb-50d4-89f7-f9d8d4f9debe
DOI
10.1101/2025.06.18.660360
Open publication

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Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinomaDOI 10.1101/2025.06.18.660360
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