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Conserved Neuronal-like and Secretory Programs Define the Spatial Architecture of Gastroenteropancreatic Neuroendocrine Tumors

2025-12-29

Abstract excerpt

<h4>ABSTRACT</h4> Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are clinically heterogeneous malignancies whose biology and microenvironmental organization remain poorly understood. Here, we integrated single-nucleus multiomic (snRNA-seq and snATAC-seq) and spatial transcriptomic profiling across 38 well-differentiated pancreatic (pNET) and small-intestinal (siNET) tumors to define conserved malignant p...

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Literature Corpus work
9a862f05-4bc0-5999-9272-d760218373e7
DOI
10.64898/2025.12.28.696762
Open publication

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