Article

A Practical Approach for Targeting Structural Variants Genome-wide in Plasma Cell-free DNA

2024-01-05

Abstract excerpt

<title>Abstract</title> <p>Interrogating plasma cell-free DNA (cfDNA) to detect cancer offers promise; however, no current tests scan structural variants (SVs) throughout the genome. Here, we report a simple molecular workflow to enrich a tumorigenic SV (DNA palindromes/fold-back inversions) that often demarcates genomic amplification and its feasibility for cancer detection by combining low-throughput next-gener...

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Literature Corpus work: 24bab286-8643-5973-b902-3d39c0beede3
DOI: 10.21203/rs.3.rs-3492157/v1

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