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A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

3 Dec 2022

Abstract excerpt

Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection and accessibility from cfDNA to study the phenotype of tumors using as low as 0.1x coverage whole genome sequencing data. Griffin employs a GC correction procedure tailored to variable cfDNA fragment sizes, which...

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PMID: 36463275
DOI: 10.1038/s41467-022-35076-w

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