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Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across <i>Aplysia</i> PRXamide and human Neuromedin U signaling

2026-07-30

Abstract excerpt

Post-translational modifications (PTMs) diversify neuropeptide function, yet how minimal modifications encode receptor specificity without direct contact remains a fundamental challenge in chemical biology. Pyroglutamylation (pQ), a prevalent N-terminal PTM in bioactive peptides, introduces a rigid cyclic constraint, yet its mechanistic role in receptor signaling is unclear. Here, using two newly identified endoge...

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Identifiers and source

Literature Corpus work
24803f8e-52c0-558d-afb7-b7848ea4de8d
DOI
10.64898/2026.07.28.741146
Open publication

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Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across <i>Aplysia</i> PRXamide and human Neuromedin U signalingDOI 10.64898/2026.07.28.741146
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