Article
Structural basis of ligand binding modes at the human formyl peptide receptor 2.
Nature communications - 5 Mar 2020
Chen Tong, Xiong Muya, Zong Xin, Ge Yunjun, Zhang Hui, Wang Mu, Won Han Gye, Yi Cuiying, Ma Limin, Ye Richard D, Xu Yechun, Zhao Qiang, Wu Beili
Abstract excerpt
The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a drug target for chronic inflammatory diseases. A variety of peptides with different structures and origins have been characterized as FPR2 ligands. However, the ligand-binding modes of FPR2 remain elusive, thereby limiting the development of potential drugs. Here we report the crystal...
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