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Article

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

1 Oct 2019

Abstract excerpt

The peptidergic system is the most abundant network of ligand-receptor-mediated signaling in humans. However, the physiological roles remain elusive for numerous peptides and more than 100 G protein-coupled receptors (GPCRs). Here we report the pairing of cognate peptides and receptors. Integrating comparative genomics across 313 species and bioinformatics on all protein sequences and structures of human class A...

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PMID: 31675498
DOI: 10.1016/j.cell.2019.10.010

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