Article

Modulation of the agonist and antagonist activity of peptidic FPR1 ligands through N-terminal modifications: A structural and functional analysis

2026-07-16

Abstract excerpt

Formyl peptide receptor 1 (FPR1) is a promising therapeutic target for the treatment of inflammatory and infectious diseases. Although multiple classes of peptides are known to modulate FPR1 activity, comprehensive studies systematically linking N-terminal modifications to binding, mechanism of action and functional outcomes remain limited. In this study, we aimed to rationalise the binding and activity of three p...

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Literature Corpus work: 5972a5a7-868c-5e32-b057-89c3dc3cd174
DOI: 10.64898/2026.07.10.737841

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