Article

Identification of key Y <sub>4</sub> R residues enables the discovery of selective non-peptide small-molecule agonists

2026-05-01

Abstract excerpt

G protein-coupled receptors (GPCRs) are central regulators of human physiology and disease, classifying them as relevant targets for therapeutic interventions. As transmembrane proteins, they convert extracellular signals into intracellular responses through agonist-induced conformational changes. Understanding how agonists stabilize active receptor conformations is decisive for rational drug design. In this study...

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Literature Corpus work: e3e56ee8-df8f-5a9c-868c-bf70bb4b6ec9
DOI: 10.64898/2026.04.27.721169

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