Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.

Frontiers in endocrinology - 1 Jan 2021

Wang Meng, Pi Linyu, Lei Xiaowei, Li Lei, Xu Jing, Kuang Zhe, Zhang Cong, Li Liang, Zhang Chao

Abstract excerpt

The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts. Melanocortin receptor accessory protein 2 (MRAP2) functions as an essential accessory player that modulates the surface translocation and binding to a variety of endogenous or synthetic hormones of central melanocortin-4 receptor (MC4R)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Body Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Chemistry

Share to Cyclic AMP

Share to HEK293 Cells

Share to Protein Conformation

Share to Receptor, Melanocortin, Type 4

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 34759891
DOI: 10.3389/fendo.2021.750797
PMCID: PMC8572914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.PMID 34759891Read ↗

Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.Semantic proximity Read ↗

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.Semantic proximity Read ↗

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiologySemantic proximity Read ↗

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variantsSemantic proximity Read ↗

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signalingSemantic proximity Read ↗

Structural determinants regulating cell surface targeting of melanocortin receptors.Semantic proximity Read ↗

Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane.Semantic proximity Read ↗

Identification of GLP1R and MCHR1 signaling as novel GPCR targets of MRAP2 proteinSemantic proximity Read ↗

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.Semantic proximity Read ↗

The G-protein coupled receptor family: actors with many faces.Semantic proximity Read ↗

The multimerization pathway of the glucocorticoid receptorSemantic proximity Read ↗

The tetraspan MS4A family in homeostasis, immunity, and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.