Article

An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission

2026-05-26

Abstract excerpt

Pentameric ligand-gated ion channels (pLGICs) mediate fast inhibitory neurotransmission critical for neuronal network stability. A tyrosine residue in the M2-M3 linker of inhibitory pLGICs, conserved for over 600 million years, is positioned where it could hydrogen bond (H-bond) to the backbone of the neighboring Cys-loop. Given the pathogenic effects of variants of this tyrosine, we hypothesized that this H-bond...

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Literature Corpus work: 71f448cb-d90f-541e-abc2-f47c22a352fc
DOI: 10.64898/2026.05.22.727206

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