Article

Substrate recognition principles for the PP2A-B55 protein phosphatase

2024-02-11

Abstract excerpt

The PP2A-B55 phosphatase regulates a plethora of signaling pathways throughout eukaryotes. How PP2A-B55 selects its substrates presents a severe knowledge gap. By integrating AlphaFold modelling with comprehensive high resolution mutational scanning, we show that α-helices in substrates bind B55 through an evolutionary conserved mechanism. Despite a large diversity in sequence and composition, these α-helices shar...

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Literature Corpus work: 3380e7ed-5fce-5647-8087-c5b4e39b10e7
DOI: 10.1101/2024.02.10.579793

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