Article

Aggregation is a context-dependent constraint on protein evolution

2021-05-11

Abstract excerpt

Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important goal. Here, we analysed two deep mutational scanning experiments to investigate the role of protein aggregation in molecular evolution. In one data set, mutants o...

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Identifiers and source

Literature Corpus work: 2472c2da-ec9a-58b4-a8d5-a18cf53a3f4c
DOI: 10.1101/2021.05.10.443436

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