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Article

Protein sequences encode safeguards against aggregation.

Human mutation - 1 Mar 2009

Reumers Joke, Maurer-Stroh Sebastian, Schymkowitz Joost, Rousseau Fréderic

Abstract excerpt

Functional requirements shaped proteins into globular structures. Under these structural constraints, which require both regular secondary structure and a hydrophobic core, protein aggregation is an unavoidable corollary to protein structure. However, as aggregation results in reduced fitness, natural selection will tend to eliminate strongly aggregating sequences. The analysis of distribution and variation of...

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Identifiers

PMID: 19156839
DOI: 10.1002/humu.20905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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