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Article

Positive Selection or Free to Vary? Assessing the Functional Significance of Sequence Change Using Molecular Dynamics.

PloS one - 1 Jan 2016

Allison Jane R, Lechner Marcus, Hoeppner Marc P, Poole Anthony M

Abstract excerpt

Evolutionary arms races between pathogens and their hosts may be manifested as selection for rapid evolutionary change of key genes, and are sometimes detectable through sequence-level analyses. In the case of protein-coding genes, such analyses frequently predict that specific codons are under positive selection. However, detecting positive selection can be non-trivial, and false positive predictions are a...

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Identifiers

PMID: 26871901
DOI: 10.1371/journal.pone.0147619
PMCID: PMC4752228

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