Article
Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness.
BMC biology - 20 Oct 2020
Schwersensky Martin, Rooman Marianne, Pucci Fabrizio
Abstract excerpt
BACKGROUND: How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed this issue through the first structurome-scale computational investigation, in which we estimated the change in folding free energy upon all possible single-site mutations introduced in more than...
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