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Codon-Resolution Analysis Reveals a Direct and Context-Dependent Impact of Individual Synonymous Mutations on mRNA Level.

Molecular biology and evolution - 1 Nov 2017

Chen Siyu, Li Ke, Cao Wenqing, Wang Jia, Zhao Tong, Huan Qing, Yang Yu-Fei, Wu Shaohuan, Qian Wenfeng

Abstract excerpt

Codon usage bias (CUB) refers to the observation that synonymous codons are not used equally frequently in a genome. CUB is stronger in more highly expressed genes, a phenomenon commonly explained by stronger natural selection on translational accuracy and/or efficiency among these genes. Nevertheless, this phenomenon could also occur if CUB regulates gene expression at the mRNA level, a hypothesis that has not...

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Identifiers

PMID: 28961875
DOI: 10.1093/molbev/msx229
PMCID: PMC5850819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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