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Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase.

Protein science : a publication of the Protein Society - 1 May 2022

Dindo Mirco, Pascarelli Stefano, Chiasserini Davide, Grottelli Silvia, Costantini Claudio, Uechi Gen-Ichiro, Giardina Giorgio, Laurino Paola, Cellini Barbara

Abstract excerpt

The conformational landscape of a protein is constantly expanded by genetic variations that have a minimal impact on the function(s) while causing subtle effects on protein structure. The wider the conformational space sampled by these variants, the higher the probabilities to adapt to changes in environmental conditions. However, the probability that a single mutation may result in a pathogenic phenotype also...

Topics

Alanine
Alleles
Mutation
Transaminases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35481644
DOI: 10.1002/pro.4303
PMCID: PMC8996469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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