Mistranslation can enhance fitness through purging of deleterious mutations.

doi:10.1038/ncomms15410

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Article

Mistranslation can enhance fitness through purging of deleterious mutations.

Nature communications - 19 May 2017

Bratulic Sinisa, Toll-Riera Macarena, Wagner Andreas

Abstract excerpt

Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with a high mistranslation rate. TEM-1 populations evolved in such strains endow host cells with a general growth...

Topics

Anti-Bacterial Agents
Drug Resistance, Bacterial
Escherichia coli
Evolution, Molecular
Gene Deletion
Gene Library
Genetic Fitness
Genotype
Models, Genetic
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Single Nucleotide

Protein Biosynthesis

Selection, Genetic

Sequence Analysis, DNA

beta-Lactamases

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Identifiers

PMID: 28524864
DOI: 10.1038/ncomms15410
PMCID: PMC5454534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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