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Longitudinal Proteogenomic Analysis Reveals Mechanistic Insights into the Progression from Prediabetes to Type 2 Diabetes

2026-02-16

Abstract excerpt

Prediabetes and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance and β-cell dysfunction. To understand the molecular mechanisms driving the transition from prediabetes to T2D, we performed a longitudinal proteogenomic analysis on 458 participants from the Prediabetes Lifestyle Intervention Study (PLIS). We identified 185 plasma proteins to be differentially expressed between condit...

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Literature Corpus work
2438e9d2-f9a8-5bcd-a8a9-6fa66b4e226a
DOI
10.64898/2026.02.13.26346161
Open publication

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Longitudinal Proteogenomic Analysis Reveals Mechanistic Insights into the Progression from Prediabetes to Type 2 DiabetesDOI 10.64898/2026.02.13.26346161
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