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Article

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk.

Cardiovascular diabetology - 9 Sept 2026

Wang Zhenqian, Su Chen-Yang, Lu Jiawen, Hasebe Masashi, Mejia-Garcia Alejandro, Tsao Hsuan Megan, Hu Jingyi, Lu Tianyuan, Zhou Sirui

Abstract excerpt

BACKGROUND: Moderate-to-vigorous physical activity (MVPA) lowers the risk of type 2 diabetes (T2D). Identifying protein modules that mediate this association may help dissect these biological underpinnings, but they remain incompletely characterized. METHODS: We studied 28,842 diabetes-free UK Biobank participants with baseline plasma proteomics. Guideline-adherent MVPA was defined as ≥ 600 metabolic equivalent...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Proteomics
Risk Factors
Exercise
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Assessment

UK Biobank

Female

Blood Proteins

Male

Biomarkers

Aged

Protective Factors

Phenotype

Risk Reduction Behavior

Protein Interaction Maps

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42778924
DOI: 10.1186/s12933-026-03363-1
PMCID: PMC13602772

Genes

CKB
IGFBP2
PCBD1
RIDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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