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Article

Linking the plasma proteome to genetics in individuals from continental Africa provides insights into type 2 diabetes pathogenesis.

Nature genetics - 1 Jan 2026

Soremekun Opeyemi, Park Young-Chan, Tutino Mauro, Arruda Ana Luiza, Kalungi Allan, Rayner N William, Nyirenda Moffat, Fatumo Segun, Zeggini Eleftheria

Abstract excerpt

Individuals of African ancestry remain largely underrepresented in genetic and proteomic studies. Here we measure the levels of 2,873 proteins in plasma samples from 163 individuals with type 2 diabetes (T2D) or prediabetes and 362 normoglycemic controls from the Ugandan population. We identify 88 differentially expressed proteins between the two groups. We link genome-wide data to protein expression levels and...

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Identifiers

PMID: 41507467
DOI: 10.1038/s41588-025-02421-w
PMCID: PMC12807854

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