Genetic reduction of PERK-eIF2α signaling in dopaminergic neurons drives cognitive and age-dependent motor dysfunction

Abstract excerpt

An array of phenotypes in animal models of neurodegenerative disease have been shown to be reversed by neuronal inhibition of PERK, an eIF2α kinase that modulates the unfolded protein response (UPR). This suggests that targeting PERK therapeutically could be beneficial for treatment of human disease. Herein, using multiple genetic approaches we show that selective deletion of the PERK in mouse midbrain dopaminergi...

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• alpha-Synuclein
• Animals, Genetically Modified
• Autophagy in Disease and Therapy
• Caenorhabditis elegans
• Endoplasmic Reticulum Stress and Disease
• Neuroblastoma
• Organ Culture Techniques
• RNA regulation and disease

Identifiers and source

Literature Corpus work

241ba8d7-3ef5-5224-870d-43ca2f5091f3

DOI

10.1101/2020.04.07.028241