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Article

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.

Acta neuropathologica - 1 Nov 2015

Radford Helois, Moreno Julie A, Verity Nicholas, Halliday Mark, Mallucci Giovanna R

Abstract excerpt

The PERK-eIF2α branch of the Unfolded Protein Response (UPR) mediates the transient shutdown of translation in response to rising levels of misfolded proteins in the endoplasmic reticulum. PERK and eIF2α activation are increasingly recognised in postmortem analyses of patients with neurodegenerative disorders, including Alzheimer's disease, the tauopathies and prion disorders. These are all characterised by the...

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Identifiers

PMID: 26450683
DOI: 10.1007/s00401-015-1487-z
PMCID: PMC4612323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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