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Article

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.

Nature neuroscience - 1 Sept 2013

Ma Tao, Trinh Mimi A, Wexler Alyse J, Bourbon Clarisse, Gatti Evelina, Pierre Philippe, Cavener Douglas R, Klann Eric

Abstract excerpt

Expression of long-lasting synaptic plasticity and long-term memory requires protein synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2 α-subunit (eIF2α). Elevated phosphorylation of eIF2α has been observed in the brains of Alzheimer's disease patients and Alzheimer's disease model mice. Therefore, we tested whether suppressing eIF2α kinases could alleviate synaptic plasticity...

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Identifiers

PMID: 23933749
DOI: 10.1038/nn.3486
PMCID: PMC3756900

Genes

APP
PSEN1

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