Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions

10 Feb 2019

Abstract excerpt

In the CNS, perivascular cells ("pericytes") associate with endothelial cells to mediate the formation of tight junctions essential to the function of the blood-brain barrier (BBB). The BBB protects the CNS by regulating the flow of nutrients and toxins into and out of the brain. BBB dysfunction has been implicated in the progression of Alzheimer's disease (AD), but the role of pericytes in BBB dysfunction in AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Barrier Structure and Function Studies
Share to Cancer Cells and Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30745035
DOI: 10.1016/j.stemcr.2019.01.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier InteractionsPMID 30745035Read ↗

Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier propertiesSemantic proximity Read ↗

Brain Pericytes and Wnt/β-Catenin Signaling Induce Functional Blood-Brain Barrier Phenotype in Human iPSC-Derived Model.Semantic proximity Read ↗

Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based modelSemantic proximity Read ↗

Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractilitySemantic proximity Read ↗

A novel human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasionSemantic proximity Read ↗

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells.Semantic proximity Read ↗

A protocol for rapid pericyte differentiation of human induced pluripotent stem cellsSemantic proximity Read ↗

Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype.Semantic proximity Read ↗

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.Semantic proximity Read ↗

Human iPSC-derived brain pericytes exhibit differences in inflammatory activation compared to primary human brain pericytesSemantic proximity Read ↗

A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte StudiesSemantic proximity Read ↗

Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.