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Ablation of telomerase reverse transcriptase in <i>Leishmania major</i> results in a senescent-like phenotype and loss of infectivity

2023-11-10

Abstract excerpt

The lack of efficient human vaccines and effective nontoxic drugs for leishmaniasis necessitates a search for new therapeutic targets. The telomere environment could provide potential targets against leishmaniasis. TERT, the telomerase reverse transcriptase component, has been on the radar for new therapeutic options against several diseases for more than two decades. In this study, we constructed a full deletion...

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Literature Corpus work
240fb7c2-fd4c-5dd9-bfa5-cba6c5e6b11e
DOI
10.1101/2023.11.10.566596
Open publication

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Ablation of telomerase reverse transcriptase in <i>Leishmania major</i> results in a senescent-like phenotype and loss of infectivityDOI 10.1101/2023.11.10.566596
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