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Miltefosine enhances infectivity of miltefosine-resistant <i>Leishmania infantum</i> by attenuating innate immune recognition

2021-02-25

Abstract excerpt

Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutations in a single aminophospholipid transporter gene can easily be selected in a laboratory environment. These mutations result in a reduced survival...

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Literature Corpus work
3d23b554-6847-56d7-9e3b-deb87991cd71
DOI
10.1101/2021.02.22.432409
Open publication

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Miltefosine enhances infectivity of miltefosine-resistant <i>Leishmania infantum</i> by attenuating innate immune recognitionDOI 10.1101/2021.02.22.432409
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