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Article

Distinct Roles in Autophagy and Importance in Infectivity of the Two ATG4 Cysteine Peptidases of Leishmania major

20 Nov 2012

Abstract excerpt

Macroautophagy in Leishmania , which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2). We have investigated the individual contributions of each ATG4 to Leishmania major by generating individual gene deletion mutants (Δ at g 4.1 and Δ at g 4.2 ); double mutants could not be generated, indicating that...

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PMID: 23166325
DOI: 10.1074/jbc.m112.415372

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