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The live attenuated <i>DGAT1</i> -knockout whole-cell <i>Toxoplasma</i> vaccine confers protective immunity against acute and chronic toxoplasmosis

2026-08-17

Abstract excerpt

The intravacuolar parasite Toxoplasma gondii scavenges fatty acids from host mammalian cells and stores excess in lipid droplets. To investigate the physiological relevance of neutral lipid storage in Toxoplasma , we generated a mutant lacking DGAT1 , an ER-localized enzyme that synthesizes triacylglycerols, from the virulent type I RH strain of T. gondii . Compared to WT, RH ΔDGAT1 parasites grow poorly in ma...

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Identifiers and source

Literature Corpus work
ea2fc1df-a3fe-5e7c-98f2-43af1f839d90
DOI
10.64898/2026.08.16.745102
Open publication

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The live attenuated <i>DGAT1</i> -knockout whole-cell <i>Toxoplasma</i> vaccine confers protective immunity against acute and chronic toxoplasmosisDOI 10.64898/2026.08.16.745102
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