Article

The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosis

2026-08-27

Abstract excerpt

<title>Abstract</title> The intravacuolar parasite <italic>Toxoplasma gondii</italic> scavenges fatty acids from host mammalian cells and stores excess in lipid droplets. To investigate the physiological relevance of neutral lipid storage in <italic>Toxoplasma</italic> , we generated a mutant lacking <italic>DGAT1</italic> , an ER-localized enzyme that synthesizes triacylglycerols, from the virulent ty...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: c9d4222f-e9bc-5746-a6b0-6a950dca9124
DOI: 10.21203/rs.3.rs-10755545/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosisDOI 10.21203/rs.3.rs-10755545/v1Read

The live attenuated DGAT1 -knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosisSemantic proximity Read

Live-attenuated Toxoplasma gondii PruΔpp2a-c mutant elicits protective immunity against toxoplasmosis in mice and catsSemantic proximity Read

Toxoplasma gondii dissemination: a parasite's journey through the infected hostSemantic proximity Read

Immunology ofToxoplasma gondiiSemantic proximity Read

Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1Semantic proximity Read

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondiiSemantic proximity Read

Toxoplasma TgATG2 works with TgATG9 and TgProp1 to drive autophagic flux for parasite extracellular survival and persistenceSemantic proximity Read

Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma.Semantic proximity Read

Correlation between the expression of lipids in the inner membrane complex of Toxoplasma gondii and its virulent phenotypesSemantic proximity Read

In vivo control of Toxoplasma gondii by zebrafish macrophagesSemantic proximity Read

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoitesSemantic proximity Read

Toxoplasma gondii Fatty Acid Elongases are Important for Virulence and PersistenceSemantic proximity Read