Article

Telomerase reverse transcriptase is required for resistance to mycobacterial infection

2025-05-18

Abstract excerpt

Age is an important risk factor for infections such as tuberculosis (TB). Telomerase is expressed in immune cells yet leukocyte telomere length declines during ageing suggesting an age-dependent loss of telomerase activity in the immune system. Leukocyte telomere length has been correlated with worse outcomes in TB patients, however the mechanisms linking telomere biology to TB susceptibility and response to thera...

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Literature Corpus work: 910cd2da-391a-585d-b281-d7321338c48e
DOI: 10.1101/2025.05.15.654386

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