Article
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
The EMBO journal - 15 May 1997
Dumas C, Ouellette M, Tovar J, Cunningham M L, Fairlamb A H, Tamar S, Olivier M, Papadopoulou B
Abstract excerpt
Parasitic protozoa belonging to the order Kinetoplastida contain trypanothione as their major thiol. Trypanothione reductase (TR), the enzyme responsible for maintaining trypanothione in its reduced form, is thought to be central to the redox defence systems of trypanosomatids. To investigate further the physiological role of TR in Leishmania, we attempted to create TR-knockout mutants by gene disruption in L....
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