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<i>Leishmania major centrin</i> knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response

2022-09-17

Abstract excerpt

<h4>Summary</h4> Leishmaniasis is a parasitic disease that is prevalent in approximately 88 countries, and yet no licensed human vaccine exists against it. Towards control of leishmaniasis, we have developed Leishmania major centrin gene deletion mutant strains ( LmCen -/- ) as a live attenuated vaccine, which induces a strong Th1 response to provide IFN-γ-mediated protection to the host. However, the immune me...

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Literature Corpus work
f2a57da1-c468-5191-a798-492a892268f7
DOI
10.1101/2022.09.15.508117
Open publication

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