Article
The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development.
Journal of autoimmunity - 1 Mar 2017
Hardtke-Wolenski Matthias, Dywicki Janine, Fischer Katja, Hapke Martin, Sievers Maren, Schlue Jerome, Anderson Mark S, Taubert Richard, Noyan Fatih, Manns Michael P, Jaeckel Elmar
Abstract excerpt
Autoimmune hepatitis (AIH) is defined as a chronic liver inflammation with loss of tolerance against hepatocytes. The etiology and pathophysiology of AIH are still poorly understood because reliable animal models are limited. Therefore, we recently introduced a model of experimental murine AIH by a self-limited adenoviral infection with the AIH type 2 antigen formiminotransferase cyclodeaminase (FTCD). We could...
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