Article
Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells.
Hepatology (Baltimore, Md.) - 1 Aug 2013
Hardtke-Wolenski Matthias, Fischer Katja, Noyan Fatih, Schlue Jerome, Falk Christine S, Stahlhut Maike, Woller Norman, Kuehnel Florian, Taubert Richard, Manns Michael P, Jaeckel Elmar
Abstract excerpt
UNLABELLED: Autoimmune hepatitis (AIH) is defined as a chronic liver disease with loss of tolerance against liver tissue eventually leading to cirrhosis if left untreated. 80%-90% of patients can be treated with a life-long immunosuppression. Unfortunately, there are strong drug-related side effects and steroid-refractory patients. Therefore, there is a need for a model system to investigate the complex...
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