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Article

Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development.

Journal of autoimmunity - 1 Mar 2006

Lapierre Pascal, Béland Kathie, Djilali-Saiah Idriss, Alvarez Fernando

Abstract excerpt

Genetic predisposition is recognized as an important factor for the development of autoimmune hepatitis (AIH). To assess the potential contribution of MHC and non-MHC genes, type 2 AIH was reproduced in three mice strains, taking advantage of their different genetic makeup with regard to MHC and non-MHC genes. Mice (C57BL/6, 129/Sv and BALB/c) were DNA vaccinated with a pCMV-CTLA4-CYP2D6-FTCD plasmid coding for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16380229
DOI: 10.1016/j.jaut.2005.11.001

Genes

FTCD
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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