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Article

Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with naïve CD8+ T cells in the mouse.

Hepatology (Baltimore, Md.) - 1 May 2004

Dikopoulos Nektarios, Wegenka Ursula, Kröger Andrea, Hauser Hansjörg, Schirmbeck Reinhold, Reimann Jörg

Abstract excerpt

Large number of T cells traffic through the liver. In order to examine the effects of such traffic on the phenotype of hepatocytes, we vaccinated mice using DNA vaccines encoding antigens with MHC class I-binding epitopes. Small numbers of activated CD8(+) T blasts (10(5)-10(6)/liver) changed the surface phenotype and cytokine expression profile of hepatocytes (HCs). HCs upregulate surface expression of major...

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Source

Identifiers

PMID: 15122754
DOI: 10.1002/hep.20173

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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