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Article

Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis.

Gastroenterology - 1 Sept 2010

Zierden Mario, Kühnen Elisabeth, Odenthal Margarete, Dienes Hans-Peter

Abstract excerpt

BACKGROUND & AIMS: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown etiology. Autoreactive T cells are thought to mediate liver injury, but the pathogenesis of AIH is poorly understood because of the lack of suitable animal models. We established a mouse model to investigate liver-specific T-cell responses and assess the effects and regulation of autoreactive CD8(+) T cells in the...

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Source

Identifiers

PMID: 20639127
DOI: 10.1053/j.gastro.2010.05.075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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