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Article

Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence

2025-03-14

Abstract excerpt

Gliomas are among the most lethal cancers, with limited treatment options. To uncover hallmarks of therapeutic escape and tumor microenvironment (TME) evolution, we applied spatial proteomics, transcriptomics, and glycomics to 670 lesions from 310 adult and pediatric patients. Single-cell analysis shows high B7H3+ tumor cell prevalence in glioblastoma (GBM) and pleomorphic xanthoastrocytoma (PXA), while most gliom...

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Identifiers and source

Literature Corpus work
c96a930f-ba6c-5486-ab42-c41f7d0a0a22
DOI
10.1101/2025.03.12.642624
Open publication

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Multi-omic landscape of human gliomas from diagnosis to treatment and recurrenceDOI 10.1101/2025.03.12.642624
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