Article

Targeting the CaVα-β interaction yields a selective antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

2018-12-10

Abstract excerpt

Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β and α2δ subunits. The β-subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. We targeted the high-affinity protein-protein interface of CaVβ’s pocket within the CaVα-s...

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Literature Corpus work: 23f0da98-c513-57b1-ae32-ae63f074c02c
DOI: 10.1101/492181

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